Preliminary Program
Thursday, November 27th | Day 1
8.00 am - 9.00 am Registration
9.00 am - 9.30 am Welcome Ceremony
**************************
9.30 am - 10.50 am Session 1: Refinement
(Chair: TBD)
Patrick Reinhardt (Bochum) - Refining operant behavioral assessment in an open-science homecage environment
Florian Alexander Dehmelt (Tübingen) - Electrical stunning as a way to kill zebrafish? Behavioural and neurophysiological effects observed in larvae
Esther Mahabir-Brenner (Cologne) - Managing old-aged mice
Speaker 4 TBD
**************************
10.50 am - 11.10 am Coffee Break
**************************
11.15 am - 1.00 pm Session 2: New Thinking in 3Rs
(Chair: TBD)
Julia Menon (Utrecht) - Does Preregistration Work? Evidence from the First Evaluation in Animal Research
Daniel Hoffmann (Essen) - Reduction of animal numbers by computational analyses that maximize information gain per animal
Speaker 7 TBD
Speaker 8 TBD
**************************
1.00 pm - 2.00 pm Lunch Break
**************************
2.00 pm - 3.20 pm Session 3: Panel
(Chair: TBD)
Short talks from selected abstracts
~~~~~~~~~~~~~~~~
Ask the experts ?! - interactive Q&A session
**************************
3.20 pm - 4.20 pm Poster Session (odd numbers) & Coffee Break
**************************
4.20 pm - 5.40 pm Session 4: Replacement
(Chair: TBD)
Joana Witt (Düsseldorf) - 3D Tissue Models of the Ocular Surface and Beyond
Ivonne Vazquez (Bonn) - Generation of Vascularized Lung Organoids for Disease Modelling
Oliver Dräger (Bielefeld) - Establishment of a Human iPSC-Derived Nociceptive Neuron Model for the Investigation of Sex-specific Differences in Migraine Pathophysiology
Yotam Menuchin-Lasowski (Münster) - Developing an iPSC-Derived Optic Nerve Model for the Study of Myelin Diseases
**************************
5.40 pm - 5.50 pm Wrap-up Day 1
**************************
From 7.30 pm and on Get-Together at CT2 in Aachen, Germany
Friday, November 28th | Day 2
8.30 am - 9.00 am Registration
**************************
9.00 am - 10.30 am Session 5: Keynote Lecture
(Chair: TBD)
Katie Bates (London) - NC3Rs: National Centre for Replacement, Refinement and Reduction of Animals in Research
**************************
10.30 am - 11.40 am Poster Session (even numbers) & Coffee Break
**************************
11.40 am - 1.00 pm Session 6: Reduction
(Chair: TBD)
Nicole Schupp (Düsseldorf) - Use of 3R-compliant methods to investigate nephro- and hepatotoxicity
Roland Ullrich (Cologne) - Lymphoma-associated myeloid-monocytic (LAMM) cells mediate resistance against CAR-T cell therapy in aggressive B-cell lymphoma
Ralf Weiskirchen (Aachen) - From Bile Duct Ligation and Carbon Tetrachloride-Induced Liver Injury to Biochips: The Evolving Toolbox of Experimental Liver Models
Speaker 21 TBD
**************************
1.00 pm - 1.15 pm Wrap-up and Closing Remarks
**************************
1.30 pm - 3.00 pm 3R-Network Meeting (for 3R-Centers, invitation only)
Venue
KASTEEL BLOEMENDAL
BLOEMENDALSTRAAT 150
6291CM VAALS
NETHERLANDS
Certification and further education points
Attendance at the Annual Meeting is certified as an advanced training course as part of the German advance training obligation in accordance with §3 TierSchVerV.
Keynote Lecture

Katie Bates
Research Funding
NC3Rs
United Kingdom
Confirmed speakers

Florian Alexander Dehmelt
Systems Neurobiology
University of Tübingen

Oliver Dräger
Cellular Neurophysiology
Bielefeld University

Daniel Hoffmann
Bioinformatics and Computational Biophysics
University of Duisburg-Essen

Esther Mahabir-Brenner
Center for Molecular Medicine
University of Cologne

Julia Menon
Scientific Daily Director
PreclinicalTrials.eu

Yotam Menuchin-Lasowski
Neuropathology
University of Münster

Patrick Reinhardt
Experimental and Molecular Psychiatry
Ruhr University Bochum

Nicole Schupp
Kidney Damage and Regeneration
University of Düsseldorf

Roland Ullrich
Translational Research for Infectious Diseases and Oncology
University Hospital Cologne

Ana Ivonne Vazquez-Armendariz
Organoid Biology
University of Bonn

Ralf Weiskirchen
IFMPEGKC
RWTH Aachen University

Joana Witt
Experimental Ophthalmology
University of Düsseldorf
We have compiled essential information regarding the 3rd Annual Meeting. A pre-conference satellite workshop will precede the meeting on November 26, 2025, at RWTH Aachen University. Please navigate the event pages to review all the details:
Pre-Conference Satellite Workshop